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Wysolone 10mg (Predenisolone)

Wysolone 10mg (Predenisolone) x30 30 $1.5 $45.00
Wysolone 10mg (Predenisolone) x60 60 $1 $60.00
Wysolone 10mg (Predenisolone) x90 90 $0.85 $76.50
Wysolone 10mg (Predenisolone) x180 180 $0.7 $126.00
Wysolone 10mg (Predenisolone) x360 360 $0.55 $198.00

Product Information

Wysolone 10 contains 10mg of prednisolone which is a synthetic corticosteroid that is used to suppress symptoms of a wide variety of allergic, immune, and inflammatory disorders. For instance, it is used to lessen inflammation in overactive immune system conditions such as severe asthma, anaphylaxis, or acute eczema outbreaks. It also lessens inflammation and suppresses the immune system in autoimmune diseases such as rheumatoid arthritis, ulcerative colitis, or systemic lupus erythematosus; and to prevent organ transplant rejection.

The active drug Prednisolone in Wysolone, is a strong anti-inflammatory, anti-rheumatic, anti-allergic, and immunosuppressant drug that acts on body tissues to alter fat, protein, calcium, and glucose metabolism.  Prednisolone reduces the inflammatory response by blocking the production of inflammatory chemicals like leukotrienes and prostaglandins produced from inflammatory cells to reduce swelling, redness, and pain associated with inflammation. Prednisolone also modifies the actions of cells associated with allergic response and it has the ability to suppress the immune system.

Wysolone may also be used with other medication as an anti-cancer drug to treat leukemia and lymphoma and to replace natural cortisol in certain endocrine disorders. This medication may also be used for other medical conditions as prescribed by a physician.


Wysolone is manufactured by Wyeth Ltd.


Wysolone is contraindicated to patients with known allergy to prednisolone and to any of the tablet’s ingredients. It is contraindicated to patients with the following medical conditions:

  • systemic infections
  • herpes simplex keratitis
  • inflammation of the optic nerve
  • live vaccination

Wysolone is also contraindicated to patients taking mifepristone.

Warnings and Precautions

Before taking Wysolone, a patient must first inform a healthcare provider of any medical conditions because it may interact with the medication. A healthcare provider must be informed if any of these apply:

  • Kidney disease
  • Liver disease
  • iabetes
  • Thyroid disorder
  • Seizure
  • Heart problems
  • Tuberculosis
  • Osteoporosis
  • Glaucoma or cataract
  • Stomach ulcer, ulcerative colitis
  • Mental problems
  • High blood pressure
  • Muscle disorder
  • Recent bacterial, fungal, or viral infection

Steroids such as prednisolone can weaken the body’s immune system which will make it prone to infection. It can also worsen an infection one currently has or it can reactivate past infections.

It is best to inform a doctor of any illness or infection one had within the past several weeks.

Wysolone may interact with other medications. A patient must inform healthcare providers if using other medications. Wysolone may interact with the following medications:

  • Prednisolone may cause an increased requirement for insulin and oral diabetes medications
  • Barbiturates, hydantoins, and rifampicin may reduce the effectiveness of prednisolone
  • Estrogens and oral contraceptives increases bioavailability of prednisolone thus increasing risk of side effects.
  • Prednisolone increases salicylate levels (aspirin)
  • Risk of convulsion is increased if prednisolone is used with ciclosporin
  • Carbimazole or carbamazepine may increase clearance of prednisolone thus reducing its effectiveness
  • Concomittant use with NSAIDs increases risk of gastrointestinal bleeding and ulceration
  • Prednisolone may decrease clearance of methotrexate thus increasing blood levels or adds risk to side effects
  • Anticoagulants or killed/inactivated vaccine effectiveness may be reduced by prednisolone

Avoid receiving live vaccine while using prednisolone for the effectiveness of vaccine may be reduced and risk of side effects increased.

Prednisolone is under Pregnancy Category D in the 1st trimester of pregnancy – there’s evidence of human fetal risk based on reports. It must only be used by pregnant women if clearly needed and if benefits outweigh the risks.

Wysolone and Alcohol

Drinking alcohol must be avoided while taking this medication as it may increase risk of undesirable effects.

Wysolone and Caffeine

It is advised to limit caffeine intake such as tea, coffee, soda, or chocolate while using this medication.



The dose, frequency, and duration of Wysolone therapy will vary per patient as it will depend on the medical condition to be treated along with other health factors. The prescribed dose must strictly be followed. The doctor may sometimes change a patient’s dose to get better results.  A patient must NOT change the dosage on his/her own.

The usual adult dosage of Wysolone tablets are as follows:

Allergic and Inflammatory disorders

  • Initial dose of 5 to 60mg per day in 2 to 4 divided doses
  • Maintenance dose of 2.5 to 15mg daily

Rheumatoid arthritis

  • Initial dose of 5 to 7.5mg per day, adjust as necessary

Multiple sclerosis

  • 200mg per day for 1 week, then 80mg every other day for 1 month

Poorly controlled, moderate to severe asthma

  • 40 to 60mg daily in 1 to 2 divided doses in 3 to 10 days

Wysolone is a dispersible tablet, a type of tablet that disintegrates in water and other liquid. Wysolone tablet must be handled with dry hands. The tablet is taken from the blister pack by peeling the back foil; the tablet must NOT be pushed through the foil. Put the tablet in the mouth and allow to dissolve without chewing. Swallow as the tablet dissolves. It may be taken with a glass of water to help swallow the dispersed tablet. Wysolone tablet should be taken with food.

Stopping Wysolone therapy should be done gradually to avoid undesirable effects.

Side Effects

All medications may cause side effects but not all patients will experience them. Some may experience minor side effects, some experience serious ones, others may have no side effects at all.

Wysolone may cause these common and less serious side effects:

  • headache, dizziness
  • nausea, stomach pain, bloating
  • mood changes
  • insomnia
  • acne, dry skin, thinning skin, facial flushing
  • slow wound healing
  • clumsiness
  • increased sweating

The doctor must be notified if any of these serious side effects occur:

  • vision problems
  • easy bruising or bleeding
  • changes in menstrual period
  • changes in skin color
  • rapid or unusual weight gain, change in shape or location of body fat in face, neck, breast, arms, waist, legs
  • mental or mood changes like severe depression
  • seizure
  • signs of pancreatitis – upper stomach pain spreading to the back, nausea, vomiting, fast heart rate
  • signs of low potassium – confusion, extreme thirst, increased urination, leg discomfort, uneven heart rate, muscle weakness
  • serious high blood pressure – blurred vision, severe headache, buzzing in ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeat
  • signs of infection – fever, chills, persisten sore throat

Wysolone may also cause the following adverse reactions:

  • Cushing’s syndrome, growth retardation in children
  • Osteoporosis, fractures
  • Peptic ulceration
  • Glaucoma, cataracts
  • Hyperglycemia, pancreatitis
  • Increased appetite, obesity

These are not complete lists of side effects, refer to drug leaflet or consult a healthcare provider for more information.

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