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Tretizen 20mg (Isotretinoin)
Qty Price per Unit Price
Tretizen 20mg (isotretinoin) x 30 $1.30 $39.00
Tretizen 20mg (isotretinoin) x 60 $1.10 $66.00
Tretizen 20mg (isotretinoin) x 90 $0.90 $81.00
Tretizen 20mg (isotretinoin) x 180 $0.75 $135.00
Tretizen 20mg (isotretinoin) x 360 $0.55 $198.00


Product Information


Tretizen 20 capsules contains 20mg of Isotretinoin as its active ingredient. Isotretinoin is a retinoid that is used to treat severe acne. Nodular acne and cystic acne are forms of severe acne causing big, deep, and painful cysts or nodules. These forms of acne can occur independently or together as nodulocystic acne. Severe acne is quite difficult to treat, and may cause scarring if left untreated.


Isotretinoin is only prescribed for severe nodular acne, only when the acne failed to improve with other acne medications.   About 85% of patients have seen improvement after one course of Isotretinoin treatment.


While the exact mechanism of Isotretinoin is unknown, the improvement of severe acne is thought to be associated with the reduction of skin oil production, changing the skin oil characteristics, and prevention of abnormal skin hardening.




Tretizen 20 is manufactured by Zenlabs India




The exact dosage per patient will be determined by a dermatologist as it will depend on the severity of the condition, weight and age of patient, and the response to treatment.


Tretizen capsules must be taken orally and swallowed whole with a glassful of water. It is taken with food to help increase the absorption of the drug to the bloodstream. Although some brands may be taken with or without food. Isotretinoin capsules are usually taken twice a day for 15 to 20 weeks.


The usual adult dose of Isotretinoin for severe recalcitrant nodular acne is 0.5mg to 1mg/kg of body weight per day by mouth in 2 divided doses. 2mg/kg per day may be needed for severe acne with scarring or severe acne on the trunk.


The usual pedriatic dose of Isotretinoin for 12 years and older is 0.5mg to 1mg/kg of body weight per day by mouth in 2 divided doses.


The acne may become worse during the first few days of taking the medication. Full benefit of the drug may be noticeable after 1 to 2 months of therapy. If the severe acne returns and requires a second course of treatment, it should only be started after at least 8 weeks of completion of the first course.


Long term use of Isotretinoin is not recommended. Strictly follow the dosage instructions of the dermatologist. Take it regularly, at the same time each day. If a dose is missed, skip the missed dose and resume regular dosing schedule. Never double the dose.




Tretizen is contraindicated if:

  • With known allergy to the active ingredient Isotretinoin or to Vitamin A, and to all the inactive ingredients of the medication
  • Pregnant, may become pregnant or planning to get pregnant
  • Breastfeeding
  • Taking tetracycline antibiotics and other vitamin A-type medications


Side effects


All medications may cause side effects but not all people taking the medication will have the same experience – some may have side effects, others may not.


The common side effects of Isotretinoin include headache, dizziness, drowsiness, chapped lips, dry eyes, mouth or skin, dry nose that may cause nosebleed, temporary worsening of acne, minor swelling of eyelids or lips, crusty skin, upset stomach and thinning of hair. Use a lip moisturizer may help prevent cracking of lips. Contact the dermatologist if any of these side effects persist or worsen.


Seek medical help right away if these rare yet serious side effects occur:

  • Mental or mood changes like depression, aggressive behavior
  • Tingling sensation on the skin
  • Sun sensitivity
  • Abnormal hair growth
  • Muscle pain or weakness
  • Fast heartbeat
  • Red patches or bruises on the legs or arms
  • Signs of infection like fever, chills, sore throat
  • Painful or difficult swallowing
  • Red, swollen, blistered or peeling of skin
  • Severe headache
  • Vision changes
  • Hearing problems
  • Chest pain
  • Yellowing of eyes or skin
  • Dark urine
  • Symptoms of increased pressure in brain including eye pressure, nausea, vomiting, vision changes
  • Symptoms of stroke like one-sided weakness, slurred speech, confusion
  • Symptoms of stomach or bowel problems like severe stomach or bowel pain, rectal bleeding, severe diarrhea
  • Pancreatitis with symptoms of severe stomach pain, severe nausea and severe vomiting


Seek urgent medical attention for any signs of allergic reaction such as rash, itching or swelling of face, throat, tongue, severe dizziness and breathing difficulty


Consult a dermatologist for more information on Tretizen side effects.


Warnings and Precautions


Use Isotretinoin (Tretizen) only with the advice of a dermatologist.  A dermatologist will prescribe this medication if it is believed to be safe for a patient.  Inform the dermatologist of the following conditions before using this medication:

  • Pregnant, planning to get pregnant or breastfeeding
  • All other prescription or OTC medicines, herbal and dietary supplements
  • Allergies to vitamin A-related drugs, other drugs, foods and other substances
  • A woman that is unable to use 2 effective forms of birth control or avoid sexual intercourse
  • History of asthma, diabetes, high blood cholesterol, heart problems, liver problems
  • History of psychiatric disorders
  • History of hearing problems, stomach or bowel problems, pancreas problems
  • Obesity
  • Eating disorders
  • Alcohol abuse
  • Bone problems
  • Irregular menstrual period    


This drug may cause increased sensitivity to the sun. Prolonged sun exposure, tanning booths and sun lamps must be avoided. The use of sunscreen and protective clothing is recommended when outdoors.


Isotretinoin may affect night vision. Caution is advised when driving and performing other activities after dark.


Donating blood while taking Isotretinoin and 1 month after use of this drug has ended, must be avoided. Cosmetic procedures to smoothen skin like waxing, dermabrasion or laser must also be avoided during and 6 months after Isotretinoin use.


Isotretinoin is under Pregnancy Category X. Animal and pregnant women studies have shown evidence of fetal abnormalities. Making the drug contraindicated in pregnant women. Women of child-bearing age must use 2 forms of birth control at least 1 month before drug use, during therapy and 1 month after therapy ends. Pregnant women must not handle this medication or inhale dust from the capsule as the drug may be absorbed through the skin and lungs.


Isotretinoin may lead to a decline in bone strength to some patients. Those who engage in vigorous sports may be at higher risk of bone problems like fractures.


Isotretinoin may affect normal growth in children. Caution is advised to use of this drug in children. Safety and efficacy in children younger than 12 years has not been established.


This drug may interact with medications such as, but not limited to:

  • Tetracyclines
  • St. John’s wort
  • Vitamin A-type medication
  • Progestin-only birth control
  • Corticosteroids
  • Anti-seizure drugs


Tretizen and Alcohol

Avoid drinking alcohol when taking Isotretinoin (Tretizen) to prevent unwanted side effects such as drowsiness, dizziness, nausea, vomiting, fast heartbeat, warmth or redness under the skin, and tingly feeling. Concomitant use may also increase the risk of pancreatitis.





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