Frusenex 100mg (Furosemide)
|Frusenex 100mg (Furosemide) x60 60||$0.6||$36.00|
|Frusenex 100mg (Furosemide) x90 90||$0.5||$45.00|
|Frusenex 100mg (Furosemide) x180 180||$0.4||$72.00|
|Frusenex 100mg (Furosemide) x360 360||$0.3||$108.00|
Frusenex contains 100mg of its active ingredient Furosemide. Furosemide is a strong diuretic or “water pill”, a drug used to help with fluid retention or edema caused by a number of medical conditions like heart failure, kidney and liver diseases. Furosemide will help reduce symptoms of swelling of the arms, legs, and abdomen. This drug is also prescribed for patients with hypertension which leads to a reduced risk of stroke, heart attack and other kidney problems.
The kidneys are responsible for filtering the blood of salt (composed of sodium and chloride), water and other small molecules. The filtered sodium, chloride and water from the blood is reabsorbed into the blood before the filtered fluid becomes urine and then eliminated from the body. Frusenex works by stimulating the excretion of excess salt and water from the kidneys, thereby increasing the volume of urine. The active ingredient Furosemide, is a loop diuretic which specifically inhibits water and salt reabsorption in the ascending limb of the loop of Henle in the kidneys, by blocking the co-transporter of sodium, potassium and chloride.
This drug may also be prescribed by a healthcare professional for other medical conditions not mentioned above.
Frusenex 100 is manufactured by Geno Pharmaceuticals Ltd.
Frusenex is contraindicated to patients with known hypersensitivity to the active ingredient Furosemide and all the inactive ingredients of the tablet. This drug is also contraindicated to patients with anuria or are unable to urinate, with renal failure, Addison’s disease, hypovolemia, dehydration, and pre-comatose state linked to liver cirrhosis
Warnings and Precautions
A physician must be informed of any drug allergies before taking Frusenex. Safety of a medication is crucial to know before intake to prevent further health damage. A physician must be informed of the following medical conditions prior to taking Frusenex in order to determine the safety in using the medication:
- Kidney disease
- Liver disease
- Risk of hypotension
- High cholesterol
- Electrolyte imbalance
- Enlarged prostate
- Bladder obstruction or other problems with urination
- Sulfa drug allergy
Frusenex may cause hypersensitivity to sun, therefore, sun exposure for long periods, tanning booths and sunlamps must be avoided. The use of sunscreen and protective clothing is recommended when going outdoors.
Frusenex may cause a reduction in potassium blood levels which may require a patient to take potassium supplements and potassium-rich diet.
Caution is advised to pregnant and lactating women. Frusenex is under Pregnancy Category C – animal studies have shown adverse effects on fetus, but there are no adequate human studies. Frusenex is known to be passed onto breast milk and may slow down breast milk production. This medication may be used by pregnant and lactating women only as prescribed by a physician, after weighing the benefits over the risks.
Frusenex may interact with other medications, causing serious side effects or change in how medications work. Ototoxic effects may be increased if Furosemide is taken concomitantly with aminoglycoside antibiotics, ethacrynic acid and cisplatin. Salicylates can reduce the diuretic effect of Furosemide and concomitant use may increase risk of salicylate toxicity. Severe hypotension may occur if Furosemide is combined with ACE inhibitors and MAOIs, and phenytoin may interfere with the renal action of Furosemide. Furosemide can antagonize the skeletal muscle effect of tubocurarine, antagonize hypoglycemic effect of antidiabetic drugs, can potentiate the action of succinylcholine and can increase nephrotoxicity of cephalisporins. It can also increase the risk of cardiotoxocity with cardiac glycosides and antihistamines. Concomitant use of Frusenex and chloral hydrate is not recommended as it may lead to flushing, sweating attacks, restlessness, nausea, increased blood pressure and tachycardia.
Increased damage to kidneys will occur if Furosemide interacts with the following medications:
- Bowel disorder medications
- Medications that prevent organ transplant rejection
- Osteoporosis and antibiotic injectable medications
- Other pain and arthritis medications
Sucralfate must be taken at least 2 hours before or after taking Furosemide because simultaneous use can reduce the hypotensive and diuretic effect of Furosemide.
Consult a healthcare professional for more information on Frusenex drug interactions.
Frusenex and Alcohol
Alcohol in combination with Furosemide (Frusenex) may cause side effects such as headache, dizziness, lightheadedness, fainting or changes in heart rate, due to the additive effects as both can lower blood pressure.
Consulting a physician is necessary before using this medication to determine the right dosage per individual. Each patient varies in dosage due to varying health factors.
Furosemide tablets has a recommended dose of 20mg to 80mg as an initial adult dose and a maintenance dose of 20mg to 40mg every 6 to 8 hours.
For edema associated with heart failure, the recommended initial dose is 40mg per day and may be reduced to 20mg per day or 40mg on alternate days. Sometimes, a higher dose of 80mg or more daily in divided doses may be used. Elderly patients should start at lower doses, an initial dose of 20mg then may be increased in necessary.
The recommended dose for hypertension is 40mg to 80mg per day, alone or in combination with antihypertensive drugs. The medication must be taken continuously even if the patient feels fine unless instructed by a physician otherwise. Hypertension usually does not present any symptoms.
Furosemide tablets are taken orally, swallowed whole with a glass of water, and may be taken with or without food. However, taking the tablet with food reduces gastrointestinal discomfort. The tablet must be taken during the day, and avoid taking it within 4 hours of bedtime to prevent sleep interruption at night due to frequent toilet breaks.
Never double the dose just to make up for a missed dose. Take the missed dose as soon as remembered, but skip it if it’s almost time for the next dose. This medication must be taken regularly to get optimum benefit. The prescribed dose must strictly be followed and must not be changed without the advice of a physician to prevent the risk of irreversible hearing loss from high doses of Furosemide.
Patients taking Frusenex may experience the following common side effects:
- Blurred vision
To prevent from getting dizzy or lightheaded, one must slowly rise from a sitting or lying position.
This medication may also cause serious dehydration because of its diuresis action. Symptoms of electrolyte imbalance may be observed. Notify a physician if any of the serious side effects are experienced:
- Muscle cramps
- Unusual tiredness
- Unusual dry mouth or thirst
- Fast or irregular heartbeat
- Severe dizziness
- Mood changes
More serious side effects are listed below. Call a physician right away for any of these side effects:
- Ringing in the ears or hearing loss
- Seizures or convulsions
- Memory or speech problems
- Jaundice (yellowing of skin or eyes, dark urine)
- Sudden weakness, fever, chills
- Pale skin, bruising or bleeding
- Nausea, vomiting, appetite loss, sweet or musty breath odor
- Severe pain in the upper stomach radiating to the back
- Symptoms of kidney problems such as little or no urination, painful or difficult urination, swollen feet or ankles, feeling of tiredness or shortness of breath
Serious cardiac arrhythmia is a potentially fatal adverse effect of Furosemide.
Stop the medication and seek urgent medical help if a severe allergic reaction occurs. Symptoms include rash, itching and swelling of face, tongue, throat, severe dizziness and breathing difficulty.
Side effects from Frusenex are not limited to the list above. Consult a healthcare provider for more information on Frusenex side effects.