Clofi 50mg (Clomifene)
|Clofi 50mg (Clomifene)x30 30||$1.5||$45.00|
|Clofi 50mg (Clomifene)x60 60||$1||$60.00|
|Clofi 50mg (Clomifene)x90 90||$0.7||$63.00|
|Clofi 50mg (Clomifene)x180 180||$0.6||$108.00|
|Clofi 50mg (Clomifene)x360 360||$0.45||$162.00|
Clofi 50 is prescribed to treat infertility in women caused by ovulation problems. This drug is most likely effective in women with Polycystic Ovary Syndrome (PCOS), amenorrhea-galactorrhoea syndrome, psychogenic amenorrhoea, post-oral-contraceptive amenorrhoea and other secondary cases of amenorrhoea. This drug is also used in treating male infertility by increasing spermatogenesis and is found effective in treating secondary male hypogonadism.
Clofi 50 contains 50mg of the active ingredient Clomiphene citrate. This drug is an anti-oestrogen which works by blocking the oestrogen receptors in the hypothalamus. Oestrogen sends negative feedback to the pituitary gland preventing it from releasing hormones that control the production and release of an egg. With blocked oestrogen receptors, the signals to the pituitary gland is stopped thereby increasing the hormones to stimulate the ovaries in making and releasing an egg for ovulation. This drug does not immediately produce an ovulation but starts a chain reaction that leads to an ovulation.
In addition to this drug in treating infertility, properly timed sexual intercourse is also necessary.
Clofi 50 is manufactured by Sunrise Remedies Pvt. Ltd.
Clofi is contraindicated to patients with known allergy to its active ingredient Clomiphene citrate, and all its inactive ingredients.
This drug must not be used by patients with the following medical conditions:
- History or current Liver problems
- Abnormal vaginal bleeding
- Hormone-dependent tumors
- Ovarian cyst unrelated to polycystic ovary syndrome
- Problem with thyroid or adrenal gland
Warnings and Precautions
Some medications are not safe to take for certain conditions, and sometimes dose adjustments are necessary to make it safe. Physicians must be notified of the following conditions before taking Clofi:
- If already pregnant or breastfeeding
- Have liver problems
- Have ovarian cysts not related to PCOS
- Have endometriosis or uterine fibroids
- Have hormone-dependent tumor
- Have heavy or unusual menstrual periods
Clomiphene is under Pregnancy Category X, although human studies is not enough, animal studies have shown evidence of fetal harm. This drug is not recommended for use in pregnant women. Clomiphene may increase the risk of having multiple pregnancy and ectopic pregnancy.
This drug is not recommended for use during breastfeeding despite not knowing if it passes into breast milk. This drug however, may reduce breast milk production.
Caution is advised when driving, using machineries or performing hazardous activities as this drug causes visual side effects.
Clomiphene are known to interact with the following drugs:
- Concomitant use of Clomiphene and Bexarotene, an anticancer drug, may increase the risk of pancreatitis.
- Concomitant use with Ospemifene, a drug used as a pain reliever during intercourse, may increase the risk of thrombus.
Clofi and Alcohol
Drinking alcohol while taking Clomiphene (Clofi) may increase risk or worsen side effects such as visual problems and dizziness.
Clofi tablets must be used as directed by a physician. The doctor may change the dose during the course of treatment, to get optimum results. The tablet must be taken by mouth, swallowed whole with a glassful of water.
50mg once a day for 5 days is the usual adult dose to induce ovulation. Therapy should start on or near the 5th day of menstruation. Intake may be started any time for women without recent menstrual period. If ovulation occurs but pregnancy is not attained, two courses of 50mg once a day for 5 days may be started 30 days after the first course of treatment. To increase chances of getting pregnant, sexual intercourse must be done during ovulation.
Patients taking the drug usually ovulate within 5 to 10 days of taking clomiphene. If the patient failed to ovulate after the first course of therapy, a second course of 100mg per day for 5 days may be started, 30 days following initial course. A third course may also be given if needed.
This drug may also be used for the suppression of lactation and for oligospermia, with an adult dose of 25 to 100mg once a day over a period of several months.
The recommended use of this medication should not exceed 3 treatment courses as it will increase the risk of having ovarian tumor. Therapy exceeding 3 courses should only be done if advised by a physician.
Common side effects of Clofi include headache, flushing, breast pain or tenderness, bleeding or spotting.
Clomiphene is known to cause a potentially life-threatening complication by overstimulation of the ovaries leading to Ovarian Hyperstimulation Syndrome (OHSS). Notify a physician right away if any of the following symptoms appear:
- Stomach pain, bloating
- Nausea, vomiting, diarrhea
- Rapid weight gains especially in the face and midsection
- Swelling of hands or legs
- Shortness of breath when lying down, or painful breathing
- Rapid heart rate
- Little or no urination
Clofi intake must be stopped and physician must be notified for any of the following side effects:
- Enlargement of ovaries characterized by pelvic pain, pressure or swelling
- Visual disturbances
- Heavy vaginal bleeding
Medication must also be stopped for signs of allergic reaction such as hives, difficulty in breathing, swelling of lips, face, throat or tongue.