Cenmox 500mg (Amoxicillin)
Cenmox 500 contains 500mg of the antibiotic Amoxicillin as its active ingredient. Amoxicillin is a beta-lactam antibiotic that belongs to the penicillin family. Being a broad-spectrum antibiotic, it is prescribed in the treatment of a wide range of bacterial infections caused by gram-positive and gram-negative bacteria. Antibacterial medications do not work in treating viral infections such as the common cold or flu. Bacterial infections that Cenmox can treat are, but not limited to the following:
- Skin infections
- Throat infections
- Bone infections
- Ear infections
- Dental infections
- Heart infections
- Kidney or genitourinary tract infections
- Nose or sinus infections
- Blood infections
- Respiratory tract infections
It is also used for the treatment of gonorrhea, typhoid and paratyphoid, and infections related to pregnancy. Amoxicillin is prescribed in conjunction with other medications for the treatment of stomach ulcer caused by Helicobacter pylori.
Amoxicillin kills bacteria by inhibiting the production of peptidoglycan, which is responsible for providing cell wall strength to bacteria. It attacks bacterial cell wall during the multiplication stage of the bacteria. Through this cell wall biosynthesis inhibition, bacteria can no longer survive inside a human body, leading to bacterial death.
Cenmox 500 is manufactured by Centurion Laboratories
Patients allergic to the active ingredient Amoxicillin or other beta-lactam antibiotics like cephalosporins, and antibiotics from the penicillin family like ampicillin, dicloxacilliin, oxacillin, or allergy to capsule excipients, must not use Cenmox.
Warnings and Precautions
One must consult a healthcare professional first, before taking Cenmox, to determine if this medication is safe for use and to prevent any drug interactions and further health damage.
A physician must be informed of any of the following conditions before using Cenmox:
- Liver disease
- Kidney disease
- History of diarrhea caused by antibiotics
- Drug allergies like allergy to cephalosporin antibiotics
- Suspected glandular fever
Amoxicillin (Cenmox) can interact with other medications and may cause undersirable effects. A physician must be informed of other medicines and supplements being taken. Below is a list of some Amoxicillin interactions with other medications.
- Amoxicillin reduces the effectiveness of birth control pills, patches or rings because it affects estrogen reabsorption.
- Combination with oral anticoagulants may require careful monitoring because of increased anticoagulation effects.
- Other antibacterial drugs such as macrolides, sulfonamides, chloramphenicol and tetracycline interferes with the effects of penicillin antibiotics including amoxicillin.
- Concomitant use with probenecid increases and prolongs amoxicillin blood levels of amoxicillin
- Concomitant use with allopurinol increases the risk of allergic reactions such as skin rash
- Penicillins including amoxicillin reduces the excretion of methotrexate, thus increasing potential toxicity
Amoxicillin can stop the effects of oral typhoid vaccine, therefore, any vaccination containing live bacteria is not recommended while taking this drug.
This medication can also cause false-positive results in urine-glucose diagnostic tests such as Clinitest, Benedict’s Solution and Fehling’s Solution.
This antibiotic should only be used by pregnant women if no safer alternative is available and if the benefit of the drug outweighs the risk. Amoxicillin (Cenmox) is under Pregnancy Category B – animal studies have shown that amoxicillin does not harm the fetus but there are not enough studies done in pregnant women.
Caution is advised to nursing mothers as amoxicillin is excreted in human milk and may cause sensitization of nursing babies.
Cenmox and Alcohol
Alcohol does not affect the action of Amoxicillin (Cenmox) but it is recommended to avoid alcohol consumption while on antibiotic therapy to help the body fight the infection.
Cenmox capsules are taken orally, with or without food, swallowed whole with a glass of water. Taking a double dose to make up for a missed dose must be avoided. A missed dose must be taken as soon as remembered, but should be skipped if it’s almost time for the next dose.
A physician must be consulted to get the right dosage of Cenmox. Each patient will vary in dosage as it will depend on the severity of infection to be treated, age or weight of patient, other health conditions and response to treatment.
The usual recommended adult dose of the following bacterial infections are:
For acute sinusitis, asymptomatic bacteriuria in pregnancy, acute pyelonephritis, dental abscess, and acute cystitis
- 250mg to 500mg every 8 hours or 750mg to 1g every 12 hours
- 750mg to 1 g every 8 hours for severe infections
- acute cystitis may bet treated with 3g twice a day for 1 day
For community acquired pneumonia, typhoid and paratyphoid fever, joint infections
- 500mg to 1g every 8 hours
For prophylaxis of endocarditis
- a single dose of 2g orally, 30 to 60 minutes prior to procedure
For treatment of Helicobacter pylori infection
- 750mg to 1g twice a day for 7 days, in combination with a proton pump inhibitor and another antibiotic
The maximum dose of Amoxicillin is 6grams daily in divided doses. The recommended duration of antibiotic therapy is 7 to 14 days although some severe infections may require longer antibiotic therapy. Take antibiotics exactly as prescribed by a physician. The antibiotic duration of therapy must be completed even if the patients starts to feel better to avoid bacterial drug resistance causing the infection to come back or get worse.
Aside from the desirable effects of the antibiotic, it may also cause unwanted side effects, but each patient has different experience or response to the medication. Some of the side effects subside as the body adjusts to the medication. The most common reported side effects of Amoxicillin are nausea, diarrhea and skin rash.
Vaginal yeast infection or oral thrush with symptoms of white patches or sores inside the mouth or on lips and changes in vaginal discharge may develop with prolonged or repeated use of this antibiotic.
Amoxicillin may rarely cause a severe intestinal condition, the Clostridium difficile-associated diarrhea, which occurs during treatment or weeks to months after drug use is discontinued. This condition has symptoms of abdominal cramps or stomach pain, persistent or severe diarrhea with blood or mucus in stool. Using of anti-diarrhea medications and narcotic pain medications must be avoided.
Seek medical help right away if any of the serious side effects occur:
- Severe diarrhea with bleeding
- Urine turning darker and feces paler
- Easy bruising or unusual bleeding of nose, mouth, rectum or vagina
- Severe skin reaction
- Severe numbness, tingling, muscle weakness
- Swollen glands
The following side effects are reported but with a rare occurrence:
- Black hairy tongue
- Tooth discoloration
- Excessive body movement
- Reduced blood cell count
- Kidney inflammation
Taking of Cenmox must be stopped if an allergic reaction occurs with symptoms like rash, itching, swelling of face, tongue or throat, severe dizziness, and trouble breathing.
Consult a healthcare professional for more information on Cenmox side effects.