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Terpafen 50mg (Clomifene)

Qty Price per Unit Price
Terpafen 50mg (clomifene) x 30 $1.50 $45.00
Terpafen 50mg (clomifene) x 60 $1.00 $60.00
Terpafen 50mg (clomifene) x 90 $0.70 $63.00
Terpafen 50mg (clomifene) x 180 $0.60 $108.00
Terpafen 50mg (clomifene) x 360 $0.45 $162.00


Product Information


Terpafen 50 contains 50mg of Clomiphene citrate as its active ingredient. Clomiphene is an anti-estrogen that belongs to a drug class called Selective Estrogen Receptor Modulator (SERM). Terpafen is used as a fertility drug for women who can’t get pregnant. It is prescribed in the treatment of infertility in women because of problems with ovulation. Clomiphene is found highly effective in women with Polycystic Ovary Syndrome (PCOS), amenorrhea-galactorrheoa syndrome, psychogenic amenorrhoea, post-oral-contraceptive amenorrhoea and other secondary cases of amenorrhoea. This drug can also be used to treat male infertility due to low sperm production and secondary male hypogonadism.


Clomiphene has both estrogenic and anti-estrogen properties. Terpafen induces ovulation by blocking estrogen receptors. It works by competing with estrogens in binding to estrogen receptors in the hypothalamus, thereby stimulating the pituitary gland to release of hormones necessary in producing and releasing an egg for ovulation. However, this drug does produce an ovulation instantly, but starts a chain reaction leading to an ovulation.


In addition to this drug in treating infertility, properly timed sexual intercourse is also necessary.




Terpafen is manufactured by Shree Venkatesh Int. Ltd.




Patients must consult a health care professional to get the right dosage of this medication. Strictly follow the prescribed dosage even if the dosage prescribed is different from the dosage stated below. During the course of treatment, a physician may change the dosage to get optimum results.


Terpafen tablets must be taken by mouth, swallowed whole with a glass of water. The usual adult dose to treat ovulation problems is 50mg once a day for 5 days. Therapy should start within the 5th day of menstrual period. Women who haven’t had previous menstruation can start the drug any time. Patients taking the drug usually ovulate within 5 to 10 days of taking clomiphene.


If pregnancy is not achieved despite having an ovulation, two courses of 50mg once a day for 5 days may be started 30 days after the first course of treatment. A physician may also gradually increase the dose up to 250mg per day. To increase chances of getting pregnant, sexual intercourse must be done during ovulation. Clomiphene may increase the risk of having multiple pregnancy and ectopic pregnancy.


If no ovulation occured after the first course of treatment, a second course of 100mg per day for 5 days may be started, 30 days following initial course. A third course may also be given if needed.


An adult dose of 25 to 100mg once a day for several months is recommended for the suppression of lactation and for oligospermia.


The recommended use of this medication should not exceed 3 treatment courses as it will increase the risk of having ovarian tumor. Therapy exceeding 3 courses should only be done if advised by a physician.




Terpafen is contraindicated in patients with known allergy to its active ingredient Clomiphene citrate, and all its inactive ingredients.


This drug must not be used by patients with the following medical conditions:

  • History or current Liver problems
  • Abnormal vaginal bleeding
  • Hormone-dependent tumors
  • Ovarian cyst unrelated to polycystic ovary syndrome
  • Pregnant
  • Problem with thyroid or adrenal gland


Side effects


Terpafen may cause the following common side effects: headache, flushing, breast pain or tenderness, bleeding or spotting.


Clomiphene is known to cause overstimulation of the ovaries called Ovarian Hyperstimulation Syndrome (OHSS) which is actually a potentially life-threatening complication. Notify a physician right away if any of the following symptoms appear:

  • Stomach pain, bloating
  • Nausea, vomiting, diarrhea
  • Rapid weight gains especially in the face and midsection
  • Swelling of hands or legs
  • Shortness of breath when lying down, or painful breathing
  • Rapid heart rate
  • Little or no urination


Terpafen intake must be stopped and physician must be notified for any of the following side effects:

  • Enlargement of ovaries characterized by pelvic pain, pressure or swelling
  • Visual disturbances
  • Heavy vaginal bleeding


Medication must also be stopped for signs of allergic reaction such as hives, difficulty in breathing, swelling of lips, face, throat or tongue.


Warnings and Precautions


Some medications are not safe to take for certain conditions, and sometimes dose adjustments are necessary to make it safe. Physicians must be notified of the following conditions before taking Terpafen:

  • If already pregnant or breastfeeding
  • Liver problems – the drug may worsen liver disease
  • Unusually large ovary
  • Ovarian cysts not related to PCOS – the drug may increase the size of the cyst
  • Endometriosis – inducing ovulation with clomiphene may make endometriosis worse
  • Uterine fibroids – the drug may increase the size of fibroid tumors
  • Hormone-dependent tumor
  • Heavy or unusual menstrual periods – the drug may worsen the condition
  • Inflamed veins due to blood clots – the drug may worsen the condition
  • Mental depression – existing mental depression may worsen during drug therapy


Clomiphene is under Pregnancy Category X. Animal studies have shown evidence of fetal harm from the drug, but there are no adequate studies in human. This drug is contraindicated in pregnancy.


It is not known whether the drug is excreted in breast milk. However, this drug can reduce production of breast milk. Caution is advised to breastfeeding women.


Caution is advised when driving, using machineries or performing other activities as this drug causes changes in vision.


Clomiphene are known to interact with only a few medications. Concomitant use of Clomiphene and Bexarotene, an anticancer drug, may increase the risk of pancreatitis. Combining with Ospemifene, a drug used as a pain reliever during intercourse, may increase the risk of thrombus.


Terpafen and Alcohol

Drinking alcohol while taking Clomiphene (Terpafen) may increase risk or worsen side effects such as visual problems and dizziness.